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Pyridine derivatives 2 cannabinoid receptor agonists
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
ATSUSHI KIMBARA,DIDIER ROMBACH,MARK ROGERS-EVANS,FABIENNE RICKLIN,MATTHIAS NETTEKOVEN,STEPHAN ROEVER,UWE GRETHER,MATTHIAS WESTPHAL,TANJA SCHULZ-GASCH
申请号:
ARP130104505
公开号:
AR093805A1
申请日:
2013.12.05
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Equation 1 compounds can be used as a drug. 1. Claim 1: a formula compound (1),R1 is halogen, halogenated phenyl, cyclomethoxy, halogenated phenyl, oxyethane, halogenated alcoxi, halogenated phenyl, halogenated phenyl or acrylonitrile lalconxi; R2 is halogen, cyclomethoxy, haloadenine, halopyridine, hydroxyethane, cyclomethoxy, cycloformyltoluene, halogenated cycloethane or haloxyethane; R3 and r83084 are hydrogen or tar, the other is - (cr8309; r8310) - (cr8311; - r831225); - r831393;O r 3 and R 8308 form a 2-oxo-5-aza-helix [3.4] octimo, halozedidini or haliprolidini with nitrogen atoms; R 8309 and R 8310e are independently selected among hydrogen, tar, cyclopentadienyl, halodienyl, cyclopentadienyl, tar, phenylacetylpropenyl, fenethanol, oxydienyl oxide, hydrazide, hydrazide, hydrazide, hydrazide, hydrazide dimethyl ester; a. Azeidinicarboroni, 2-oxa-6-azaarboni [3.3] - heptabromodiphenyl ether, rental carbide, diklaminocarbonilo, carbamate, Azerbaijani, oxetanilquil and tar; or r8309a and r83100a, plus carbon atoms (connected with them), to form cyclopentanediol, oxetanilo, oxanilo or dioxin;R831181 and r831222 are independently selected among hydrogen, tar and cyclopentadiene; or r831183 and r831222 form cyclopentadiene together with the carbon atoms connected with them; r831393 is tar, oxycarbide, hydroxyl, hydrofluorosulfonyl, carbamate, cyanogen, pyridylene, hired carbide, sulfur-2-alkyl, oxazil-2-ilo, 5-l [1.2, (4) Heptabromide, 5-phenyl - [3, 5-phenyl - [1, 3, 3, 3]]]]]]]]]]]]]]]] - nitroenedinitrodidinitrodidinitrogen page: 12. The condition is that if R3 and r83088 are rented at the same time, R1 and R2 are not both halogens; or a salt or a pharmaceutically acceptable ester.El compuesto de la fórmula 1 puede utilizarse como medicamento. Reivindicación 1: Un compuesto de la fórmula (1), en la que: R¹ es halógeno, halofenilo, cicloalquilalcoxi, halofenilalquilo, oxetaniloxi, haloalcoxi, halofenilalcoxi o alquiloxetanilalcoxi; R² es halógeno, cicloalquilo
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