WOLFGANG SCHMIDT,IAN LINNEY,FABIO RANCATI,CHRIS KNIGHT
申请号：
ARP130104532
公开号：
AR093832A1
申请日:
2013.12.05
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Preparation process, compounds containing these ingredients, therapeutic use and combination with other active pharmaceutical ingredients. Claim 1: a compound characterized by a general formula (1), wherein q is a set of formulas (2),(3) And (4)；Z is h or h, chosen from y and y, which are different sets of equations (5) or (6),respectively, where A¹ and A² are independently absent or are selected from the group consisting of C₁₋₆ alkylene,C₃₋₈ cycloalkylene and C₃₋₈ heterocycloalkylene optionally substituted with one or more substituents selected from the group consisting of C₁₋₆ alkyl,C₁₋₆ arylalkyl and C₁₋₆ heteroarylalkyl；B is absent or is selected from the group consisting of C₃₋₈ cycloalkylene,3. Straight propylenea. Arileno and heteromorphic, optionally replaced by one or more groups selected from halogen, nitro, tar c832131；C₁₋₆ alkoxy,aryl, Cila arylalkyl,-8311 (r83212) and unorthodox law； C and C are absent, or from --- I...-OC (o) - y-c (OO) - or one of the residues of the formula group (7),R8311th,R⁷ and R⁸ are independently H or are selected from the group consisting of linear or branched C₁₋₆ alkyl, C₃₋₈ cycloalkyl,cycloalkyl C₃₋₈alkyl C₁₋₆,heterocycloalkyl C₃₋₈alkyl C₁₋₆,aryl and arylalkyl C₁₋₆,optionally substituted with one or more substituents selected from the group consisting of C₁₋₆ alkyl,C₁₋₆ haloalkyl,a. Halogen atom, alcox c832131；D is absent or is selected from the group consisting of C₁₋₆ alkylene,Arileno, heterosexual and heterosexual c83231；a. Selectively replacing 832626 with one or more c832131 rental groups；n. N, m and P are independent of 0 or 1 to 3, and are absent or selected from - o-y-oc (o)；G. arileno, oxo (= O) can be replaced by one or more alternatives selected from the halogen atom group,-SH, -NO₂,-CN and -NH₂；R¹ and R² are independently H or are selected from the group consisting of C₁₋₆ alkyl and aryl, optionally substituted with one or more halogen atoms； M is -N (R³) -；R³ is H or C₁₋₆ alkyl；R83088 is a formula group (8)；An
