MICHAEL C. MYERS,R. MICHAEL LAWRENCE,HEATHER FINLAY,HANNGUANG J. CHAO,WEI MENG
申请号：
ARP160103719
公开号：
AR106948A1
申请日:
2016.12.02
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a compound characterized by the formula (1), or a stereoisomer, enantiomer, a diastereois u00f3mero,A taut u00f3mero or a Salt that is acceptable from the point of view of pharmaceuticalWhere: ALK is c u2081 u208b u2086 alkyl substituted with 1 - 5 r u2074； The Ring is selected regardless of aryl and heteroaryl 5 or 6 members comprising 1 to 4 carbon Atoms and heteroatoms.Ccionados or nr u00b3 u1d43, N, and S, each substituted with 1 to 4 r u00b3； Ring B is selected regardless of aryl, heteroaryl and cycloalkyl,Each replaced with 1 - 4 r u00b9； r u00b9 is selected regardless of H, halogen, no u2082, - (ch u2082) u2099or u1d47 (ch u2082) u2099s (OR) u209ar u1d9c, - (ch u2082) u2099c (= o) - (r u1d47, u2099nr u1d43r u1d43 ch u2082), - (ch u2082) u2099cn (ch u2082 u2099c (, -) nr u1d43r u1d43 (= o) - ch u2082) (= OR) r u1d47, u2099nr u1d43c- (ch u2082) u2099nr u1d43c (= o) - (nr u1d43r u1d43, ch u2082) u2099nr u1d43c (= o) - (or u1d47, ch u2082) u2099oc (= o) - (nr u1d43r u1d43, ch u2082) u2099c (= o) - (or u1d47, ch u2082) u2099s ( u209anr u1d43r u1d43 - (OR), (OR) u209anr u1d43r u1d43 u2099nr u1d43s ch u2082), - (ch u2082) u2099nr u1d43s (OR) u209ar u1d9c, c u2081 u208b u2084 alkyl substituted with 0 - 3 r u1d49,- (ch u2082) u2099 - c u2083 u208b u2086 carbociclilo replaced with 0 - 3 and - r u1d49 (ch u2082) u2099 - heterociclilo replaced with 0 - 3 r u1d49； R u00b2 is selected regardless of c u2082 u208b u2085 alkyl substituted with 0 - 3 r u1d49 c u2082 u208b u2085 alquenilo substituted；With 1 - 3 r u1d49, aryl substituted with 0 - 3 r u1d49, heterociclilo replaced with 0 - 3 r u1d49 and c u2083 u208b u2086 cycloalkyl substituted with 0 - 3 r u1d49； provided that, when R u00b2 is c u2082 u208b u2085 alkylAnd the carbon Atom groups and linked to this, except that is attached to the pyrimidine ring, can be replace by o, N and S； r u00b3 is selected regardless of H, halogen, - ( u2099or u1d47, ch u2082)- (ch u2082) u2099s (OR) u209ar u1d
