MICHAEL J. DART,PHILIP R. KYM,ERIC A. VOIGHT,ANURUPA SHRESTHA,JEROME F. DAANEN,TAMMIE K. JINKERSON,RYAN G. KEDDY,SRIDHAR PEDDI,ARTHUR GOMTSYAN,MICHAEL E. KORT,GREGORY A. GFESSER,KEVIN R. WOLLER,DEREK
申请号：
ARP120104827
公开号：
AR089333A1
申请日:
2012.12.19
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Pharmaceutical composer 1. Claim 1: a formula compound (1) or a salt, wherein G is formula (2),(3)O (4)；R7491 is hydrogen or tar； Y1 is ch8322e Y2 is O； or Y1 is CR1 7491； r74955；E Y2K is ch832222；where R¹ᵃ is hydrogen, and R¹ᵇ is hydrogen or NR¹ᶜR¹ᵈ where R¹ᶜ is hydrogen or alkyl, and R¹ᵈ is - (Cquile-alkylenyl) -OH or - (C al-alkylene) -O (alkyl),O rc1758080 and r74969,They combine with nitrogen atoms to form a selected single ring between the groups consisting of morphine and oxazenpanilo, or Y1 is NR1, Y2 is ch832222；where R¹ is hydrogen, alkyl, or - (C₁₋₆ alkylenyl) -OH； Rᶜ is hydrogen or alkyl； Y³ is CR³ᵃR³ᵇ,and Y⁴ is O； where R³ᵃ and R³ᵇ are independently hydrogen or alkyl； or Y³ and Y⁴ are CH₂；O Y3 is NR3, y83088 is ch832222；R3 is hydrogen or asphalt； r74969 is hydrogen or asphalt； r74955；In each case, it is an alternative to bicyclic (2) benzobicycles,(3)And (4)And it is independent asphalt, halogen, or halogen； q is 0, 1, 2, or 3； Z is o or s； X1 is ch1832222；o. O n (r695), wherein r695e is hydrogen, tar or brine tar； a is ch or N； L is one or ch832222；It is connected with the ring carbon atom containing X1；N is 1, 2, or 3； m is 0, 1, 2, 3 or 4； r739；In each case, it is an optional substitute for any replaceable carbon atom in the ring containing a, and each r739e is an independent tar, halogen, halogen, Oh or (TAR) form.O (halogen)NH.8322；No (H) (lessor)O n (TAR) 832222；P equals 0, 1, 2, 3, 4, 5, or 6； r696 in each case represents an alternative to any replaceable carbon atom in the ring containing x1,and each Rʸ is independently alkyl, haloalkyl, - (C₁₋₆ alkylene) -O (alkyl),G1,Y - (codenil c83216c831832626) - G1, where each G1 is equal to or different, and is an optional alternative consisting of 1, 2, 3 or 4 alternatives independently selected from a group consisting of bitumen, halogen, halogen or (bitumen),And O (halide)；Two r6966 groups are combined on the same carbon atom, and the carbon atoms connected with them can optionally form a single cyclop
