BAUMANN KARLHEINZ,GREEN LUKE,LIMBERG ANJA,LUEBBERS THOMAS,THOMAS ANDREW
申请号：
IN6876/CHENP/2013
公开号：
IN2013CN06876A
申请日:
2013.08.26
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
123222222212The present invention relates to compounds of formula (l) hetaryl I is a five or six membered heteroaryl group containing 1 to 3 heteroatoms selected from S or N hetaryl II is a six membered heteroaryl group containing 1 to 3 heteroatoms selected from S or N or is a two membered ring system containing 1 to 4 heteroatoms selected from S or N wherein at least one ring is aromatic in nature R is lower alkyl lower alkoxy lower alkyl substituted by halogen or halogen R is lower alkyl lower alkyl substituted by halogen halogen lower alkoxy cycloalkyl substituted by lower alkyl or lower alkyl substituted by halogen or is lower alkyl substituted by hydroxy or is furyl or is O benzyl (CH2)p phenyl optionally substituted by halogen lower alkoxy lower alkyl substituted by halogen lower alkyl or by cyano R is hydrogen or lower alkyl Y is (CH)n CHOCH CHO CHS CHSCH and is bonded to two of the ring carbon atoms bonding being to either the ring carbon atoms a and b or the ring carbon atoms c and d p is 0 or 1 m is 0 1 or 2 if m is 2 then R may be the same or different 75 n is 2 or 3 o is 0 1 or 2 if o is 2 then R may be the same or different or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus they may be useful for the treatment or prevention of a disease associated with the deposition of ß amyloid in the brain in particular Alzheimers disease and other diseases such as cerebral amyloid angiopathy hereditary cerebral hemorrhage with amyloidosis Dutch type (HCHWA D) multi infarct dementia dementia pugilistica and Down syndrome.
