A compound of Formula (I) ** Formula ** and pharmaceutically acceptable forms thereof in which A is carbonyl, thiocarbonyl or sulfonyl； X is a bond or -CH>； = CH-； R1 is selected from (1). aryl optionally substituted by one or more of lower alkyl, - (CH2) n-CF3, lower alkoxy, alkoxycarbonyl, cyano or halogen； or (2). C5-C15 cycloalkyl optionally substituted by one or more of lower alkyl, - (CH2) n-CF3, lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen； n is 0, 1, 2, 3 or 4； Y is a link or -CH2-； X2 is - (CH2) m- where m is 1 or 2； R2 is -N + (R4R5) -ZR3； Z is - (CH2) p- where p is>； =, 1 or 2； R3 is selected from (1). aryl optionally substituted with one or more lower alkyl, - (CH2) n-CF3, lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen； (2). C5-C15 cycloalkyl optionally substituted with one or more of lower alkyl, - (CH2) n-CF3, lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen； or (3). heterocyclyl optionally substituted with one or more lower alkyl, - (CH2) n-CF3, lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen； wherein, when the heterocyclyl is linked through a member of the carbon atom ring and a member of the heteroatom ring is adjacent to said carbon atom, then p is 1 or 2； and R5 are each individually lower alkyl or lower alkenyl； alternatively R4 and R5 combine with the nitrogen atom of Formula (I) to form a heterocyclyl ring of 5 to 9 total ring atoms optionally containing one of an oxygen or sulfide ring atom, wherein the nitrogen atom of the heterocyclyl ring is substituted with one or more of lower alkyl or lower alkenyl to form a quaternary salt, and wherein -ZR3 is absent and the heterocyclyl ring is optionally substituted with aryl optionally substituted with one or more of lower alkyl, - (CH2) n-CF3, lower alkoxy, aryl, halogen-substituted aryl, alkoxycarbonyl, cyano or halogen.Un compuesto de Fórmula (I)**Fórmula** y formas fa
