CHEN, AUSTIN CHIH-YU,DUBE, DANIEL,FOURNIER, PIERRE-ANDRE,GRIMM, ERICH L.,LACOMBE, PATRICK,LALIBERTE, SEBASTIEN,MACDONALD, DWIGHT,MACKAY, D. BRUCE,MCKAY, DANIEL JAMES,WU, TOM YAO-HSIANG,CAMPEAU, LOUIS-
申请号：
ES09741617
公开号：
ES2548134T3
申请日:
2009.05.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I, or a pharmaceutically acceptable salt thereof, having formula (I) ** Formula ** in which: R1 is selected from the group consisting of: C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C3-C6 cycloalkenyl and C2-C6 alkynyl, wherein each of the groups mentioned above is optionally substituted with 1-3 halogens and / or C1-C5 alkoxy； R2 and R3 are independently selected from the group consisting of: hydrogen, halogen, C1-C5 alkyl, C3-C8 cycloalkyl, C2-C5 alkenyl, C3-C8 cycloalkenyl, C2-C5 alkynyl, cyano, C1-C5 alkoxy, aryl and heteroaryl, wherein said heteroaryl contains 1 to 3 heteroatoms, independently selected from the group consisting of: N, O and S, wherein each N is optionally in the form of an oxide and each S is optionally in the form of an oxide selected from the group consisting of: S (>； = O) and S (>； = O) 2, wherein said aryl and heteroaryl are optionally substituted with 1-4 halogens, wherein said alkyl, cycloalkyl, alkenyl , cycloalkenyl, alkynyl and alkoxy are optionally substituted with 1-3 substituents, each of which is independently selected from the group consisting of: halogen, C1-C5 alkyl, C2-C5 alkenyl, cyano and C1-C5 alkoxy, in which each of the substituents alkyl, alkenyl and alkoxy mentioned The above waves are optionally substituted with 1-3 halogens； W is cyclopropyl, unsubstituted or mono, di, tri, tetra or fluorinated pentas, X is hydrogen, Z is C1-C2 alkylene optionally substituted with 1-2 substituents, independently selected from the group consisting of: halogen, C1 alkyl -C3 and C3 cycloalkyl, wherein the above-mentioned alkyl and cycloalkyl substituents are optionally substituted with 1-3 halogens； n1 is 0 or 1； Y is (i) a saturated or unsaturated five or six membered carbocyclic heterocyclic or monocyclic ring ("monocyclic ring") or (ii) a saturated or unsaturated five or six membered heterocyclic or carbocyclic ring that is fused to a heterocyclic ring or saturated or unsaturated carbocyclic of five or six
