CHENG, Hengmiao,JOHNSON JR., Theodore Otto,KATH, John Charles,LIU, Kevin Kun-Chin,LUNNEY, Elizabeth Ann,NAGATA, Asako,NAIR, Sajiv Krishnan,PLANKEN, Simon Paul,SUTTON, Scott Channing
申请号：
ES12780286
公开号：
ES2575710T3
申请日:
2012.09.10
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** in which X is N or CR7； And it is absent, or is O, S or NR8； Q, T, V and W are each, independently, C or N, provided that at least two of Q, T, V and W are N and at least one of Q, T, V and W is C, since provided that when Q and T are N, at least one of R1 and R2 is absent, and also on condition that when T and V are N, at least one of R2 and R3 is absent； R1 and R4 each, independently, is absent, or is hydrogen, cyano, difluoromethyl, trifluoromethyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, -N (R9) (R10), C3-C5 cycloalkyl or 4-6 membered heterocycloalkyl, the C1-C6 alkyl may be optionally substituted by halogen, hydroxy, C1-C6 alkoxy or N (R11) (R12)； R2 and R3 each, independently, is absent, or is hydrogen, C1-C6 alkyl, C2-C6 alkynyl, C1-C6 alkoxy, C3-C7 cycloalkyl and 3 to 7 membered heterocycloalkyl, wherein C1-C6 alkyl and C1-C6 alkoxy of R2 and R3 are each, independently, optionally substituted with one or more R13 groups, and further wherein the C3-C7 cycloalkyl and the 3 to 7 membered heterocycloalkyl of R2 and R3 are each, independently, optionally substituted with one or more R14 groups； or R1 and R2 or R2 and R3 can be combined to form a C5-C7 cycloalkyl ring or a 5- to 7-membered heterocycloalkyl ring, in which the C5-C7 cycloalkyl ring and the 5- to 7-membered heterocycloalkyl ring are each , independently, optionally substituted with one or more R13 groups； Ring A is C3-C10 cycloalkyl, 3-10 membered heterocycloalkyl, C5-C10 aryl or 5-12 membered heteroaryl； R5 and R5a each, independently, is absent, or is halogen, cyano, hydroxy, difluoromethyl, trifluoromethyl, C1-C3 alkyl, C1-C3 alkoxy, C3-C5 cycloalkyl or 4- to 6-membered heteroaryl, with C1- alkyl being C3 optionally substituted with hydroxy, difluoromethyl, trifluoromethyl, C1-C3 alkoxy or C3-C5 cycloalkyl； R6 is: ** Formula ** Z is absent when the junction point of R6 in ring A is a nitrogen atom, and Z is -NR17- when the junction point of
