BROUGH, STEPHEN,EVANS, RICHARD,LUKER, TIMOTHY JON,RAUBO, PIOTR
申请号：
ES08776162
公开号：
ES2525716T3
申请日:
2008.06.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I): ** Formula ** wherein: R1 and R2 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, halo, CF3, and CN； R1a is hydrogen； R3 is hydrogen； R4 is selected from H, methyl, ethyl, methoxy, ethoxy, Cl, Br, CN, phenyl and CONH2, where methyl is optionally substituted with an NR12R13 group； R5 is selected from NR16R17 and heterocycloalkyl； R6 is selected from H, (C1-C4) alkyl, (C1-C4) alkoxy and (C3-C6) cycloalkyl； R7 is selected from H, (C1-C4) alkyl, (C1-C4) alkoxy and (C3-C6) cycloalkyl； R16 is selected from H, aryl, (C3-C7) cycloalkyl and wherein said (C3-C7) cycloalkyl can be optionally substituted with an aryl group； R17 is selected from H, (C1-C6) alkyl, aryl, heteroaryl, heterocycloalkyl and (C3-C7) cycloalkyl, wherein said (C1-C6) alkyl can be optionally substituted with 1, 2, or 3 groups independently selected from (C1-C6) alkoxy, (C3-C10) cycloalkyl, heterocycloalkyl, heteroaryl and NR20R21； R22 is selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, OH, NR29R30, heterocycloalkyl and aryl, wherein said (C1-C6) alkyl can be optionally substituted with 1, 2, or 3 R28 groups ； and wherein said aryl can be optionally substituted with 1, 2, or 3 groups independently selected from (C1-C6) alkyl, (C1-C6) alkoxy, halo, CF3 and OH； R23 is selected from H and (C1-C6) alkyl； or R22 and R23 together with the carbon atom to which they are attached form a (C3-C7) cycloalkyl or heterocycloalkyl ring； X is a link or group (CR24R25) n； R24 and R25 are independently selected from H, (C1-C6) alkyl, (C1-C6) alkoxy, OH, heterocycloalkyl and NR39R40； or R24 and R25 together with the carbon atom to which they are attached can form a heterocycloalkyl ring； Z is an aryl or heteroaryl ring, wherein said aryl or heteroaryl ring is substituted with R26 and R27.Un compuesto de fórmula (I):**Fórmula** en donde : R1 y R2 se seleccionan independientemente de H, (C1-C6)alquilo, (C1-C6)alcoxi, halo, CF3, y CN； R1a es hidrógeno； R3 es hidrógeno； R4 se selecciona
