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DERIVATIVES OF N-[(7-AZA-BICYCLO[2.2.1]HEPT-1-YL)-ARYL-METHYL]-BENZAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
专利权人:
发明人:
DARGAZANLI GIHAD,ESTENNE BOUHTOU GENEVIEVE
申请号:
IN2163/MUMNP/2011
公开号:
IN2011MN02163A
申请日:
2011.10.17
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
The inventions relates to the compounds of formula (I) where: R is a hydrogen atom or a group selected from the (C1d- C6)alkyl and (C3-C7)-cycloalkyl groups, optionally substituted by one or more groups independently selected from a fluorine atom, the (C3-C7)-cycloalkyl, (C2-C4)alkenyl, phenyl, (C1-C6)alkoxy, and hydroxy groups the phenyl group being optionally substituted by one or more (C1-C6)alkoxy groups R1 is a phenyl group optionally substituted by one or more substituants independently selected from halogen atoms, the (C1-C6)alkyl, (C1-C6)alkoxy, halo-(C1C6)alkyl, hydroxy, halo-(C1-C6)alkoxy, (C1-C6)alkyl-thio, and (C1-C6)alkyl-SO2 groups R2 is one or more substituants selected from hydrogen atoms, halogen atoms, the halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)alkyl, (C1C6)alkoxy, (C1C6)alkyl-thio, and (C1-C6)alkyl-SO2 groups in the form of a base or an addition salt to an acid. The invention further relates to the use thereof in therapy and to a method for synthesizing same.
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