CHAPPI Tomas Allen (US),ЧАППИ Томас Аллен (US),KHENDERSON Zhaklin Luiz (US),ХЕНДЕРСОН Жаклин Луиз (US),YANG Dzhozef Majkl (US),ЯНГ Джозеф Майкл (US),UEJDZHER Trevis T. (US),УЭЙДЖЕР Трэвис Т. (US),KORM
申请号：
RU2018125942
公开号：
RU0002712455C1
申请日:
2017.01.09
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to novel heterocyclic compounds of formula I or pharmaceutically acceptable salts thereof, where R1 is selected from a group consisting of hydrogen and C1-C6-alkyl； where C1-C6-alkyl is optionally substituted with one substitute independently selected from halogen, hydroxy or C1-C3-alkoxy； R2 is C1-C3-alkyl； is 0 or 1； R3 is selected from a group consisting of hydroxy, C1-C6-alkyl and C1-C6-alkoxy, where each of C1-C6-alkyl and C1-C6-alkoxy is optionally substituted with 2–3 fluorine atoms； R4 is hydrogen； A is selected from a group consisting of phenyl and 6-member heteroaryl, 1 or 2 ring atoms in 6-member heteroaryl are nitrogen and the remaining ring atoms are carbon； and where phenyl and 6-member heteroaryl are optionally substituted with 1 R6； R5 is selected from a group consisting of halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C6-alkyl, C3-C7-cycloalkoxy, phenoxy, 4–6-member heterocycloalkyl and 5–6-member heterocycloalkoxy, where 1 ring atom in heterocycloalkyl and heterocycloalkoxy is oxygen, and the remaining ring atoms are carbon； where C1-C6-alkyl, C1-C6-alkoxy and C1-C6-alkoxy-C1-C6-alkyl is optionally substituted with one or two substitutes independently selected from halogen or hydroxy； and where C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C6-alkyl, C3-C7-cycloalkoxy, phenoxy, 4–10-member heterocycloalkyl and 4–10-member heterocycloalkoxy are optionally substituted with one to two R7； R6 is selected from a group consisting of halogen, and C1-C6-alkyl； or R5 and R6, when they are bonded to adjacent carbon atoms and taken together with adjacent carbon atoms to which they are bonded, form a condensed tetrahydropyrine or tetrahydrofuran ring which is optionally substituted with one or two R8； R7 in each case is independently selected from a group consisting of halogen, hydroxy, C1-C3-alkyl optionally substituted with three f
