MJULLER DZHORDZH V.,МЮЛЛЕР Джордж В. (US),CHEHN RODZHER S.K.,ЧЭНЬ Роджер С.К. (US),RACHELMEN ALEKSANDER L.,РАЧЕЛМЕН Александер Л. (US)
申请号：
RU2009111273/04
公开号：
RU0002448101C2
申请日:
2007.08.29
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention describes a compound of formula (I): or pharmaceutically acceptable salt thereof, or stereoisomer, in which: n equals 0 or 1 X denotes CH2, C=O R1 denotes a) -(CH2)mR3 or -CO(CH2)mR3, where m equals 0, 1 and R3 denotes a 5-10-member aryl or heteroaryl, where the heteroaryl denotes a mono- or bicyclic aromatic ring containing 5-10 ring atoms, from which at least one or two atoms are heteroatoms selected oxygen, nitrogen or sulphur, optionally substituted with one or more halogens b) -C=YR4, where Y denotes O and R4 denotes: (C1-C10)alkyl (C1-C10)alkoxy (C0-C10)alkyl-(5-10-member heteroaryl), where "heteroaryl" denotes a mono- or bicyclic aromatic ring containing 5-10 ring atoms, from which at least one or two atoms are heteroatoms selected from oxygen, nitrogen or sulphur, said heteroaryl is optionally substituted with one or more substitutes selected from halogen, oxo or 2-(C1-C6)alkyl, where Z denotes S (C0-C10)alkyl-(5-10-member aryl), said aryl is optionally substituted with one or more substitutes selected from halogen (C1-C6)alkoxy, which itself is optionally substituted with one or more halogens (C1-C6)alkyl, which itself is optionally substituted with one or more halogens or -Z-(C1-C6)alkyl, where Z denotes S or SO2, and where said (C1-C6)alkyl can be optionally substituted with one or more halogens or (C1-C6)alkyl-CO-O-R12, where R12 denotes H or (C1-C6)alkyl or c) -C=ZNHR6, where Z denotes O or S and R6 denotes: (C1-C10)alkyl (C1-C10)alkoxy 5-10-member aryl or heteroaryl, where "heteroaryl" denotes a bicyclic aromatic ring containing 9 ring atoms, from which at least one or two atoms are oxygen atoms optionally substituted with one or more substitutes selected from halogen cyano (C1-C6)alkoxy, which itself is optionally substituted with one or more halogens (C1-C6)alkyl, which itself is optionally substituted with one or more halogens and R2 denotes H or (C1-C6)alkyl. Also described is a pharmaceutical composition for i
