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2-aminocarbonyl-pyridine derivatives
专利权人:
ACTELION PHARMACEUTICALS LTD.
发明人:
CAROFF, EVA,HILPERT, KURT,MEYER, EMMANUEL
申请号:
ES07826720
公开号:
ES2473609T3
申请日:
2007.10.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula IP ** Formula ** in which R 1 represents a phenyl optionally substituted once by a substituent selected from the group consisting of halogen, methyl, methoxy, trifluoromethyl and trifluoromethoxy; W represents a bond and R2 represents hydrogen, halogen, (C1-C7) alkyl, hydroxy (C1-C7) alkyl ,, (C1-C6) alkoxy (C1-C7) alkyl, cycloalkyl, aryl or heteroaryl; or W represents -O- or -S- and R2 represents (C1-C7) alkyl, cycloalkyl, aryl or heterocyclyl; oW represents - NR3-, R2 represents (C1-C7) alkyl ,, hydroxy (C1-C7) alkyl, or (C1-C6) alkoxy (C1-C7) alkyl, and R3 represents hydrogen or (C1-C7) alkyl; or W represents -C-C- and R2 represents hydroxy (C1-C7) alkyl or (C1-C6) alkoxy (C1-C7) alkyl; or W represents -NR3- and R2 and R3 form, together with the nitrogen that carries them, a 4- to 7-membered heterocyclic ring in which the members necessary to complete said heterocyclic ring are each independently selected from -CH2 - and -CHRx-, it being understood however that said heterocyclic ring contains only one member -CHRx-, Rx representing hydroxyl, hydroxymethyl, methyl (C1-C6) alkoxy or methyl (C1-C6) alkoxy; or also W represents -NR3- and R2 and R3 form, together with the nitrogen that carries them, an imidazolyl, pyrazolyl, 1,2,3-triazolyl or 1,2,4-triazolyl ring, which ring may optionally be substituted with a methyl group; each of R4 and R5 independently represents hydrogen or methyl; R6 represents (C1-C6) alkoxy; and Y represents (C1-C6) alkylene or phenylalkylene, and Z represents -OH, -COOH, cyano, tetrazolyl or -COOR7, R7 representing (C1-C7) alkyl; it being understood that: - The term "aryl" refers to a phenyl or naphthyl group; Any aryl group may be substituted with one to three substituents, each independently selected from the group consisting of halogen, (C1-C7) alkyl and (C1-C6) alkoxy.Un compuesto de fórmula IP **Fórmula** en la que R1 representa un fenilo opcionalmente sustituido una vez por un sustituyente seleccionado del grupo q
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