HENG, RICHARD,HOEGENAUER, ELIZABETH KATE,KOCH, GUIDO,PULZ, ROBERT ALEXANDER,VULPETTI, ANNA,WAELCHLI, RUDOLF
申请号：
ES12761655
公开号：
ES2548414T3
申请日:
2012.07.07
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof； ** Formula ** wherein, R 1 is hydrogen, C 1 -C 6 alkyl optionally substituted by hydroxy； R2 is hydrogen or halogen； R3 is hydrogen or halogen； R4 is hydrogen, R5 is phenyl optionally substituted by halogen； SF5； NR6R7； hydroxy； C1-C6 alkoxy； C1-C6 alkenyl； C1-C6 alkyl carbonyl； C1-C6 alkyl optionally substituted by hydroxy, halogen, or C1-C6 alkoxy； or C3-C6 cycloalkyl optionally substituted by halogen, hydroxy, or C1-C6 alkyl optionally substituted by halogen； or R5 is a 4-14 membered mono- or bicyclic heterocyclyl or heteroaryl ring system comprising 1, 2 or 3 heteroatoms selected from N, S and O with that ring being optionally substituted by halogen； hydroxy； C1-C6 alkoxy optionally substituted by hydroxy or halogen； or C1-C6 alkyl optionally substituted by hydroxy or halogen； or R4 and R5 together with the atoms to which they are attached form a piperidone ring, optionally comprising a fused phenyl ring, any such ring being optionally substituted by C1-C6 alkyl, C1-C6 alkoxy, or C3-C6 cycloalkyl, each of which substitution members may optionally be substituted by halogen or hydroxy； R6 and R7 are independently selected from hydrogen or C1-C6 alkyl； or R6 and R7 together with the nitrogen atom to which they are attached form a 4-8 membered saturated azacycloalkane ring, optionally substituted by halogen, hydroxy or C1-C6 alkyl； X is O, S (O) n where n is 0, 1 or 2, or is absent； where q is 2 or 3, and R10 is or X is CH or N； and R10 is hydrogen, hydroxy, -NR6R7, -CO-R11, -S (O) p-R12 where p is 1 or 2, R 11 is C1-C6 alkyl optionally substituted by hydroxy, cyano, halogen, carboxy or C1 -C6 alkoxycarbonyloxy； or NR6R7； and R12 is C1-C6 alkyl or NR6R7.Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo；**Fórmula** en donde, R1 es hidrógeno, C1-C6 alquilo opcionalmente sustituido por hidroxi； R2 es hidrógeno o halógeno； R3 es hidrógeno o halógeno； R4 es hidrógeno, R5 es
