BOUSBA, Sarah,GOLDBY, Anne,JENKINS, Kerry,KINSELLA, Natasha,TEALL, Martin
申请号：
ES14750620
公开号：
ES2665675T3
申请日:
2014.08.07
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula ** (See formula) ** where: R1 represents a C5-C10 aryl group that is optionally substituted by at least one substituent independently selected from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2 alkenyl C6, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylcarbonyl, C1- alkylcarbonyloxy C6, C1-C6 alkoxycarbonyl, -NR6R7, -CONR8R9, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy or C3-C6 cycloalkylmethyl； R2 represents a hydrogen or fluorine atom or a hydroxyl group, C1-C3 alkoxy or trifluoromethoxy and R3 represents a hydrogen atom, or R2 and R3 can together form a carbon-carbon bond； X represents a CHR4 group； R4 represents a hydrogen atom or, when R3 represents a hydrogen atom, R4 together with R2 can form a carbon-carbon bond； m is 1 or 2； R5 represents a 5-6 membered heteroaryl group having one or more ring nitrogen atoms as the only ring heteroatoms, where the heteroaryl group is optionally substituted by at least one substituent independently selected from halogen, cyano, C1-C6 alkyl , C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylsulfinyl, C1-C6 alkylsulphonyl, C1-C6 alkylcarbonyloxy , C1-C6 alkoxycarbonyl, -NR10R11, -CONR12R13, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy or C3-C6 cycloalkylmethyl； R6 and R7 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C6 cycloalkyl group, or R6 and R7 together with the nitrogen atom to which they are attached can form an optionally substituted 4 to 7 membered saturated heterocyclic ring by halogen or hydroxy； R and R9 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R8 and R9 together with the nitrogen atom to which they are attached can form a saturated 4- to 7-membered heterocyclic ring； R10 and R11 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C6 cycloalkyl group, or R10 and R11 togeth
