NGUYEN, DUY,VON BONIN, ARNE,HAERTER, MICHAEL,SCHIROK, HARTMUT,MENGEL, ANNE,VON AHSEN, OLIVER,SCHAEFER, MARTINA
申请号：
ES08773585
公开号：
ES2385118T3
申请日:
2008.06.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compounds of general formula (I) ** Formula ** in which R1 represents (i) an optionally substituted or identical mono- or polysubstituted aryl or heteroaryl ring with hydroxyl, -NR7R8, -NR6-C (O) -R11, -NR6 -C (O) -OR11, -NR6-C (O) -NR7R8, -NR7-SO2-R11, cyano, halogen, C1-C6 alkoxy, -OCF3, -CF3, C1-C6 alkyl, C3 cycloalkyl -C6 and / or heterocyclyl having 3 to 8 ring atoms, or (ii) a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl radical, optionally mono-opolis substituted identical or differently with hydroxyl, -NR7R8, -NR6-C (O) R11, -NR6-C (O) -OR11, -NR6-C (O) -NR7R8, -NR6-SO2-R11, cyano, halogen, C1-C6 alkoxy, -OCF3, - CF3, C1-C6 alkyl, C3-C6 cycloalkyl and / or heterocyclyl, or (iii) a C3-C8 cycloalkyl or a heterocyclyl ring having 3 to 8 ring atoms and optionally mono- or polysubstituted identically or differently with hydroxyl, -NR7R8, -NR6-C (O) -R11, -NR6-C (O) -OR11, -NR6-C (O) -NR7R8, -NR6-SO2-R11, cyano, halogen, C1 alkoxy -C6, -OCF3, -CF3, C1-C6 alkyl, C3-C6 cycloalkyl and / or heterocyclyl having 3 to 8 ring atoms, R2 represents (i) hydrogen, (ii) hydroxyl, halogen, cyano, nitro, -CF3, -OCF3, -C (O) OR11, -C (O) OH, -C (O) NR7R8, -C (S) NR7R8, -NR7R8, -NR6-C (O) -R11, -NR6- C (O) -OR11, -NR6-C (O) -NR7R8, -NR6-SO2-R11, or (iii) an optionally mono-C1-C6 alkyl or C1-C6 alkoxy radical identical or halogen-odically substituted polysubstituted , hydroxyl, C1-C6 alkoxy, -CF3, -OCF3 or -NR7R8, or (iv) an optionally mono- or polysubstituted C3-C8 cycloalkyl ring identical or differently with halogen, hydroxyl, C1-C6 alkoxy, -CF3, -OCF3, -NR7R8 and / or C1-C6 alkyl, R3 represents a C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl radical, a C3-C7 cycloalkyl or a ring, a heterocyclyl ring having 3 to 8 atoms, or a monocyclic heteroaryl ring, in each case itself optionally mono- or polysubstituted identically or differently with hydroxyl, -C (O) OR11, -C (O) NR7R8, -NR7R8, cyano, halogen, -CF3, C1-C6 alkoxy, -OCF3 and / or C1-C6 alkyl, R4 represents hydrogen, -SO2R11, -C
