Claim 1: A compound of the formula (1) and its solvates, pharmaceutically acceptable N-oxides, salts and prodrugs, wherein R¹ is hydrogen, halogen, alkyl, alkoxy, alkylthio, alkenyl, alkylcarbonyl, alkoxycarbonyl, alkynyl, alkylthioalkyl, alkoxyalkyl, SF₅,1. Thiophosphor, methyl picolinate, phenyl, furan, in which each carbon group can be replaced by one or more halogen atoms； R2 is hydrogen, halogen, tar, alcoxi, hydrocarbon group, alquenilo, tar, alcoxicarbolini, tar, alcodioquilo, alcoxiquilo, sf8325；thiophenyl, imidazolyl, phenyl, furanyl wherein each of the carbon-containing radicals is optionally substituted by one or more halogen atoms； R³ is hydrogen, halogen or alkyl, wherein each carbon atom of the alkyl is optionally substituted by one or more halogen atoms； R⁴ is hydrogen, alkyl or alkylcarbonyl； R⁵ is hydrogen, alkyl or alkylcarbonyl； R⁶ is hydrogen, alkyl, phenyl or benzyl； R⁷ is hydrogen, alkyl, phenyl or benzyl； or R⁶ binds together with R⁴ to form a C₁₋₃ alkylene group and / or R⁷ binds together with R⁵ to form a C₁₋₃ alkylene group,wherein in each or both of said C₁₋₃ alkylene groups are optionally substituted by one or more C₁₋₃ alkyl radicals；N is 1-3； X is co, CS or so 83222；b. D is n or cr831222, wherein r831222 is hydrogen, and at least B is n； a is heteromorphic, selected from the aromatics composed of 6 members according to formula (2) and the heteroaromatics composed of 5 members according to formula (3),In formula (2): Y1,And...Y8308e y83099 may be n or cr831393,There, at least one, at most three Y1,And...Y8308e y8309a is n； Y3 is cr1.83044；R⁹ is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitrile, nitro, alkylsulfonyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulfonyl, amino, dialkylamino, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, alkylcarbonylamino where each of the carbon-containing radicals is optionally substituted by one or more halogen atoms； R¹⁰ is hydrogen, alkyl, alkoxy, al
