A biodegradable intraocular implant in the form of sphere or microsphere, the implant uncomponente prostamide and biodegradable polymer matrix comprising wherein the prostamide component prostamidacomprende one or prostamide derivative represented by the following formula (I) or an acceptable salfarmacéuticamente thereof: ** ** Formula where the dashed lines represent a single or double bond, which may be OTRANS in the cis configuration A is an alkylene or alkenylene radical having from two to six carbon atoms, which radical may estarinterrumpido with one or more radicals oxide and substituted with one or more hydroxy, oxo, alkyloxy oalquilcarboxi, wherein said alkyl radical comprises from one to six carbon atoms B is a radicalcicloalquilo having three to seven carbon atoms, or selected from radicaleshidrocarbilo aryl and heteroaryl having from four to ten carbon atoms, aryl radical wherein the seselecciona heteroatom from nitrogen, oxygen and sulfur X is selected from -OR4 and -N (R4) 2in radical wherein R4 is selected from hydrogen, a lower alkyl radical having from one to six decarbono atoms, and ** ** ** Formula Formula R5 ** it is a lower alkyl radical having from one to six carbon atoms Z is> = O or represents two radicaleshidrógeno one of R1 and R2 is> = O, -OH or a -O (CO) R6 group and the other is -OH or -O (CO) R6, or R1 is> = O and R2 is H R6 is a saturated or unsaturated having 1 to 20 carbon atoms, or R6 is acyclic hydrocarbon group - (CH2) mR7en m is 0 or an integer of 1 to 10, and R7 is a cycloalkyl radical having from three decarbono seven atoms or R7 is a hydrocarbyl aryl or heteroaryl radical, as defined above for B provided deque when B is not substituted with a radical containing a heteroatom bonded and Z is> = O, then X is not -OR4.Un implante intraocular biodegradable en forma de esfera o microesfera, comprendiendo el implante uncomponente de prostamida y una matriz de polímero biodegradable en el que el componente de prostamidacomprende una p
