LIU, JIN-JUN,TILLEY, JEFFERSON WRIGHT,ZHANG, ZHUMING
申请号：
ES08750071
公开号：
ES2377245T3
申请日:
2008.05.06
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of the formula OH Ia Ib I in which X is chosen from the group consisting of hydrogen, halogen, cyano, nitro, ethynyl and cyclopropyl, Y is hydrogen or fluorine, R1, R2, R3 and R4 are chosen from the group formed by hydrogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkynyl, aryl, substituted aryl, cycloalkyl, provided that one of R1 / R2 or R3 / R4 is hydrogen and the other is not hydrogen and R5 is chosen from group consisting of hydrogen, lower alkyl or substituted lower alkyl, wherein lower alkyl refers to an alkyl group having 1 to 6 carbon atoms； lower alkoxy refers to an alkyl group with 1 to 6 carbon atoms attached to an oxygen atom； lower alkenyl refers to a straight or branched chain hydrocarbon group containing a double bond and having 2 to 6 carbon atoms； lower alkynyl refers to an unsaturated linear or branched chain aliphatic hydrocarbon group containing a triple bond and having 2 to 6 carbon atoms； aryl refers to phenyl, naphthyl, tolyl or xylyl； "substituted aryl" refers to phenyl, naphthyl, tolyl or xylyl substituted by 1-3 substituents independently selected from the group consisting of halogen, lower alkoxy, lower alkyl, carboxy, carboxy lower alkoxy and CN； Cycloalkyl refers to a C3-C6 cycloalkyl and its pharmaceutically acceptable salts.Un compuesto de la fórmula O H Ia Ib I en las que X se elige entre el grupo formado por hidrógeno, halógeno, ciano, nitro, etinilo y ciclopropilo, Y es hidrógeno o flúor, R1, R2, R3 y R4 se eligen entre el grupo formado por hidrógeno, alquilo inferior, alcoxilo inferior, alquenilo inferior, alquinilo inferior, arilo, arilo sustituido, cicloalquilo, con la condición de que uno de R1/R2 o R3/R4 sea hidrógeno y el otro no sea hidrógeno y R5 se elige del grupo constituido por hidrógeno, alquilo inferior o alquilo inferior sustituido, en donde alquilo inferior se refiere a un grupo alquilo que tiene de 1 a 6 átomos de carbono； alcoxi inferior se refiere un grupo alquilo con 1 a 6 átomos de carbono uni
