The present invention is concerned with indolin-2-one derivatives of general formulawherein A is phenyl or a six membered heteroaryl group, containing one or two N atoms, selected from,or； R1is S(O)2lower alkyl, S(O)2NR4R5, S(O)2cycloalkyl, S-lower alkyl or S(O)2-azetidin-1-yl； R4and R5are independently from each other hydrogen, lower alkyl or (CH2)2OCH3； or the group A-R1may form together with two neighboring carbon atoms from the group A an additional fused ring, selected fromor； R2is hydrogen or cycloalkyl； R3is methyl or halogen； n is 1 or 2； X is N, N+O-or CH； --- the dotted line may be nothing or -CH2-； as well as with a pharmaceutically acceptable salt thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used in the treatment of diseases or disorders recited in the specification .本發明係關於具有以下通式之吲哚啉-2-酮衍生物：， 其中 A 為苯基或選自以下的含有一或兩個N原子之五或六員雜芳基：； R1為S(O)2低碳烷基、S(O)2NR4R5、S(O)2環烷基、S-低碳烷基或S(O)2-氮雜環丁烷-1-基；R4及R5彼此獨立地為氫、低碳烷基或(CH2)2OCH3； 或基團A-R1可與該基團A之兩個鄰近碳原子一起形成選自以下之另一稠環：； R2為氫或環烷基； R3為甲基或鹵素； n 為1或2； X 為N、N+O-或CH； --- 虛線可無意義或為--CH2-； 以及其醫藥學上可接受之鹽；外消旋混合物；或其相應對映異構體及/或光學異構體及/或其立體異構體。 該等化合物可用於治療如說明書所述之疾病或病症。
