AHNAOU, ABDALLAH,安 艾达,安 艾達,DRINKENBURG, WILHELMUS H. I. M.,卓威翰,卓威翰,PALUMBO, JOSEPH M.,白乔瑟,白喬瑟,SPORN, JONATHAN,施强生,施強生
申请号：
TW095120134
公开号：
TWI419681B
申请日:
2006.06.07
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I):or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atomsx is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3R1and R2can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylallkyl, cycloalkyl of 3 to 7 carbon atomsR1and R2can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.本發明係關於一種治療個體之白天過度嗜睡(EDS)的方法,其步驟包括投與治療有效量的式(I)化合物:或其醫藥上可接受之鹽或酯;其中Rx係選自包括氫;含1至8個碳原子低烷基;選自F、Cl、Br和I中之鹵素;含1至3個碳原子烷氧基;硝基;羥基;三氟甲基以及含1至3個碳原子硫烷氧基之基的成員之一;x係1至3的整數,其條件為當x為2或3時R可相同或不同;R1和R2可彼此相同或不同且獨立選自包括氫、含1至8個碳原子低烷基、芳基、芳烷基、含3至7個碳原子環烷基之基;R1和R2可結合形成被選自一員包括氫、烷基和芳基之基所取代的5至7-員雜環,其中該環狀化合物包含1至2個氮原子及0至1個氧原子,其中該氮原子未直接相互連接或與氧原子相連接。
