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Nuevos derivados de 6-triazolopiridazin-sulfanil benzotiazol y bencimidazol, su procedimiento de preparación, su aplicación como medicamentos, composiciones farmacéuticas y nueva utilización como inhibidores de Met
专利权人:
SANOFI
发明人:
ALBERT, EVA,BACQUE, ERIC,NEMECEK, CONCEPTION,UGOLINI, ANTONIO,WENTZLER, SYLVIE
申请号:
ES08845285
公开号:
ES2436657T3
申请日:
2008.08.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Products of formula (I b): in which - R represents a hydrogen atom or a chlorine atom or the radical: Rb represents a halogen atom or an S-heteroaryl radical optionally substituted by a radicalelegido between halogen atoms and hydroxyl radicals, alkyl and alkoxy groups containing 1 to 4 decarbono atoms, NH2, NHalk and N (alk) 2 W represents a hydrogen atom or an alkyl or COR radical in which R represents : -a radical optionally substituted with OCH3 alkyl or NR3R4, -a cycloalkyl radical - an alkoxy radical optionally substituted with OCH3 or NR3R4 radical or O- (CH2) n-OCH3, or O- (CH2) n-NR3R4 radical a radical O-phenyl or O- (CH2) n-phenyl, where n represents an integer of 1 to 2, - or the radical NR1R2, wherein R1 and R2 are such that one of R1 and R2 represents an atom hydrogen, one radicalcicloalquilo or an alkyl radical and the other of R1 and R2 represents an alkyl radical optionally sustitu gone conNR3R4 or R1 and R2 form with the nitrogen atom to which they are attached, a cyclic radical containing from 3 aeslabones and optionally containing one or more further heteroatoms selected from O, S, N and NH with NR3R4 such that R3 and R4, identical or different, represent a hydrogen atom or an alkyl or bienR3 and R4 form with the nitrogen atom to which they are attached, a cyclic radical optionally containing one ovaries different heteroatoms selected from O, S, N and NH, being this radical, including the optional quecontiene NH, optionally substituted with one or more radicals chosen from alkyl radicals the radical term alkyl or Alk which designates an alkyl radical containing from 1 to 6 carbon atoms, the cycloalkyl radical term designating a saturated carbocyclic radical containing 3 to 10 decarbono atoms, with alkoxy term designating a radical containing 1 to 4 carbon atoms, the heteroaryl term designating a monocyclic or bicyclic radical containing from 5 to 12 ring members, wherein said products of formula (Ib) in all the possible isomeric forms, racemic, e
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