"6- (6-nh-substituted-triazolopyridazine sulfanyl) benzothiazoles and benzimidazole derivatives: preparation, use as medicines and use as inhibitors of met"
ANTONIO UGOLINI,CONCEPTION NEMECEK,ERIC BACQUE,SYLVIE WENTZLER
申请号：
BRPI1008188
公开号：
BRPI1008188A2
申请日:
2010.02.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to novel products of the formula (I) where: (II) is a single or double bond； Rb is a hydrogen or fluorine atom； Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical； X is S, SO, or SO2； A is NH or S； W is H, alkyl, or COR with R being cycloalkyl； alkyl； alkoxy； O-phenyl； &mdash；O&mdash； (CH2)n-phenyl with n=1 to 4； or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl； or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH； all of said radicals being optionally substituted； wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
