6- (6-O-substituted-triazolo pyridazine sulfanyl) benzothiazoles and benzimidazole derivatives: preparation, use as medicaments and use as metal inhibitors
ANTONIO UGOLINI,CONCEPTION NEMECEK,DOMINIQUE BACQUE (FALECIDO),ERIC BACQUE,SYLVIE WENTZLER
申请号：
BRPI1008232
公开号：
BRPI1008232A2
申请日:
2010.02.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to novel products of the formula (I) where: (II) is a single double bond； Ra is -O-Z-Rc with Z being a single bond or optionally substituted alkylene and Rc being optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl； Rb is H or F； if Rb is H, then Rc is not cycloalkyl when Z is a single bond, and Rc is not heterocycloalkyl when Z is alkylene； X is S, SO or SO2, A is NH or S； W is H, alkyl, cycloalkyl or COR with R being cycloalkyl； alkyl； alkoxy； O- phenyl； -O-(CH2)n-phenyl with n = 1 to 4； or NR1 R2 with R1 is H or alk and R2 is H, cycloalkyl or alkyl； or R1, R2 form a cycle with N optionally containing O, S, N and/or NH； wherein all of these radicals are optionally substituted, and said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.
