6- (6-O-cycloalkyl or 6-nh-cycloalkyl-triazolo pyridazine sulfanyl) benzothiazoles and benzimadazole derivatives: preparation, use as medicaments and use as metal inhibitors
Antonio Ugolini,Baptiste Ronan,Conception Nemecek,Dominique Damour (Falecido),Eric Bacque,Sylvie Wentzler
申请号：
BRPI1011354
公开号：
BRPI1011354A2
申请日:
2010.02.04
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The invention relates to novel products of the formula (I) where: - - - - is a single or double bond； Ra is -O-cycloalkyl or -NH-cycloalkyl； X is S, SO or SO2, A is NH or S； W is H, alkyl or COR with R being cycloalkyl； alkyl； alkoxy； O-phenyl； -O-(CH2)n-phenyl with n = 1 to 4； or NR1R2 with R1 is H or alk and R2 is H, cycloalkyl, heterocycloalkyl, or alkyl； or R1, R2 form a cycle with N optionally containing O, S, N and/or NH； wherein all of said radicals are optionally substituted； and wherein said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.
