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DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
专利权人:
发明人:
NEMECEK CONCEPTION,UGOLINI ANTONIO,WENTZLER SYLVIE,BACQUE ERIC,DAMOUR DOMINIQUE
申请号:
IN3166/KOLNP/2011
公开号:
IN2011KN03166A
申请日:
2011.07.26
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
(II) is a single double bond Ra is -O-Z-Rc with Z being a single bond or optionally substituted alkylene and Rc being optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl Rb is H or F if Rb is H, then Rc is not cycloalkyl when Z is a single bond, and Rc is not heterocycloalkyl when Z is alkylene X is S, SO or SO2, A is NH or S W is H, alkyl, cycloalkyl or COR with R being cycloalkyl alkyl alkoxy O- phenyl -O-(CH2)n-phenyl with n = 1 to 4 or NR1 R2 with R1 is H or alk and R2 is H, cycloalkyl or alkyl or R1, R2 form a cycle with N optionally containing O, S, N and/or NH wherein all of these radicals are optionally substituted, and said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.
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