DERIVADOS DE ISOTIAZOLO-PIRIMIDINDIONA COMO MODULADORES DE TRPA1

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专利权人:

GLENMARK PHARMACEUTICALS S.A.

发明人:

KUMAR, SUKEERTHI,THOMAS, ABRAHAM,MARGAL, SANJAY,MUKHOPADHYAY, INDRANIL,KHAIRATKAR-JOSHI, NEELIMA

申请号：

PE0017032011

公开号：

PE07642012A1

申请日:

2010.03.22

申请国别(地区):

PE

年份:

2012

代理人:

摘要：

Refers to a compound of formula I, where y and Z are each S N R1 and R2 are each h, hydroxyl, alkyl, cycloalkyl, haloalquilo, alquenilo, among others R3 is H, alkyl, hydroxyl, haloalquilo, alquenilo, among others l is a Linker - CO - NH -, among others is aryl or substituted or unsubstituted, Such as isotiazol, thiazole, oxazole, isoxazole, thiophene, among others V is H, halogen, Nitro, cyano,Hydroxyl alkyl, among others. Preferred compounds are: 2 - (5,7-dimethyl - 4.6 - [4,5,6,7 tetrahydro - - [1,2] tiazolo [3,4-d] - 3 - il pyrimidin-2-yl) - N - (4 - [3 - (trifluoromethyl) phenyl] - 1.3 - thiazol-2-yl} acetamide n - (4 - [4 - (Difluoromethoxy) - 1.3 - 3-fluorophenyl] thiazol-2-yl} - 2 - (5,7-dimethyl - 4.6 - [4,5,6,7 tetrahydro - - [1,2] [- d] pyrimidine tiazolo 5.4 - 3 - il) AC Etamida.REFERIDA A UN COMPUESTO DE FORMULA I, DONDE Y y Z SON CADA UNO S, N R1 Y R2 SON CADA UNO H, HIDROXILO, ALQUILO, HALOALQUILO, ALQUENILO, CICLOALQUILO, ENTRE OTROS R3 ES H, HIDROXILO, ALQUILO, HALOALQUILO, ALQUENILO, ENTRE OTROS L ES UN LIGADOR -CO-, -NH-, ENTRE OTROS U ES ARILO SUSTITUIDO O NO, TALES COMO TIAZOL, ISOTIAZOL, OXAZOL, ISOXAZOL, TIOFENO, ENTRE OTROS V ES H, CIANO, NITRO, HALOGENO, HIDROXILO, ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(5,7-DIMETIL-4,6-DIOXO-4,5,6,7-TETRAHIDRO[1,2]TIAZOLO[3,4-d]PIRIMIDIN-3-IL)-N-{4-[3-(TRIFLUOROMETIL)FENIL]-1,3-TIAZOL-2-IL}ACETAMIDA N-{4-[4-(DIFLUOROMETOXI)-3-FLUOROFENIL]-1,3-TIAZOL-2-IL}-2-(5,7-DIMETIL-4,6-DIOXO-4,5,6,7-TETRAHIDRO[1,2]TIAZOLO[5,4-d]PIRIMIDIN-3-IL)ACETAMIDA.

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