ATKINSON, FRANCIS LOUIS,BARKER, MICHAEL DAVID,LIDDLE, JOHN,WILSON, DAVID MATTHEW
申请号：
PE0020372013
公开号：
PE09982014A1
申请日:
2012.03.08
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relating to compounds of formula (i) wherein: X is CR1 or n, R1 is H, alkyl or alkoxy C1 C1 - 6 - 6 and is n or CH, C R2 is H, 6 - alkoxy C1, Halo, - C (o) - alkyl C1 - 6 ns, among others alkoxy R3 is H, or C1 - 6 M and N are integers chosen independently of 1 and 2.Preferred compounds are: 7 - (3 - (4 - [1-methyl-2 - (2-pyridinyl) oxy] methyl] - 2-pyridinyl) - 2,3,4,5 - tetrahydro - 1H - 3 - benzazepina 1 - [4 - [(2 - piridinilmetil) oxy] - 3 - (1,2,3,4 tetrahydro - 6 - - isoquinolinil) phenyl] ethanone among others. Also referred to a Pharmaceutical composition. These compounds are inhibitors of the Spleen Tyrosine Kinase (SYK) to be useful for the treatment of cancerREFERIDO A COMPUESTOS DE FORMULA (I) DONDE: X ES CR1 O N, R1 ES H, ALCOXI C1-6 O ALQUILO C1-6 Y ES CH, C O N R2 ES H, ALCOXI C1-6, HALO, -C(O)-ALQUILO C1-6, CN, ENTRE OTROS R3 ES H O ALCOXI C1-6 m Y n SON NUMEROS ENTEROS SELECCIONADOS INDEPENDIENTEMENTE DE 1 Y 2. SON COMPUESTOS PREFERIDOS: 7-(3-{[(4-METIL-2-PIRIDINIL)METIL]OXI}-2-PIRIDINIL)-2,3,4,5-TETRAHIDRO-1H-3-BENZAZEPINA 1-[4-[(2-PIRIDINILMETIL)OXI]-3-(1,2,3,4-TETRAHIDRO-6-ISOQUINOLINIL)FENIL]ETANONA ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA CINASA DEL BAZO (SYK) SIENDO UTILES PARA EL TRATAMIENTO DE CANCER
