MARRA, ANDREA,IPPOLITO, JOSEPH A.,KANYO, ZOLTAN F.,BHATTACHARJEE, ASHOKE,DUFFY, ERIN M.
申请号：
ARP180101717
公开号：
AR112201A1
申请日:
2018.06.19
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a formula compound (1),Or more than one Taurus, or an acceptable salt on a drug selected from a compound or Taurus, characterized by: J selecting (2) or (3) from a formula compound；X is selected from the heterocyclic ring and phenyl of 5 or 6 members, in which each heterocyclic ring of 5 or 6 members and selectively substituting one or more Rx for phenyl； Z is selected from the formula compound (4) or (5)；R1 selects c83218833318323 from H；e.Alquenilo C83228331832424；RZ varies from h to c8321883238a；R3 º from h to c8332188331c83323；O r 2 and R 3, together with the nitrogen atoms they connect and the carbon atoms that connect the two nitrogen atoms, form a five to six constituent ring； O R1 and R3, together with the nitrogen and sulfur atoms and the carbon atoms connecting the two nitrogen atoms, form a ring of 5 or 6 members； r83088 is selected from H and c-83218331；R83099 was selected from H and C 83217c8331832626；R8310 from h, Aquilo c83217c8331832626；A. alquenilo c832283316e and cyclo c832331832626；1. In lease No. c83218c831832626, one or more substitutes selected from the halogen group or74919 are selected to replace it；SR7491,-C（O）Or7491，-SC（NH）NH832222；cycloquilo C833238832626；E. isopropene from 3 to 6 members； r831111 was selected from H and tar c833218331832626；O r8310a and r8311a, together with the carbon and nitrogen atoms attached to them, form a ring, which contains one of formulas (6) or (7), in which c833218331832626 tar can be selected to replace the carbon atom of the ring；C. c8321c8331832626 tar can be optionally replaced by one or more Oh； or r83099 and r831181, together with the carbon atom connected and the nitrogen atom connected with the two carbon atoms, form a ring (8) with one of the formula group formulas,A. the ring can be replaced selectively in the carbon atom of the ring； q is selected from c833212o (o) tar；C831222 is selected from H and halogen, and each Rx is selected independently from halogen, c832183318326 asphalt；Haloge
