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Dérivé sulfonamide ayant une activité antagoniste de récepteur PGD2
专利权人:
Shionogi & Co.; Ltd.
发明人:
申请号:
EP11008294.8
公开号:
EP2407453A1
申请日:
2006.09.25
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
A compound of the general formula (I) for use in the treatment of diseases associated with a PGD2 receptor:wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is hydroxyalkyl etc.; R2 is independently a halogen atom etc.; R3 is a hydrogen atom etc.; R4 is independently a halogen atom etc.; R5 is independently a halogen atom etc.; M is carbonyl etc.; Y is a single bond etc.; L1, L2 and L3 are independently a single bond etc.; R6 and R7 are independently a hydrogen atom etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s), and the ring C is a benzene ring, b) the ring C is not an indole ring or an azaindole ring, c) R1 is not carboxy when the ring C is a benzene ring, -L3- is - (O-alkylene)-, and the substituting position of L3 and Y is an ortho-position each other in the ring C, and d) the substituting position of L3 and Y is not a para-position in the ring C when the ring B is a thiazolidine ring and the ring C is a benzene ring;a pharmaceutically acceptable salt or solvate thereof.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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