1. Characteristic requirement 1: a compound whose characteristic is formula (1),Or a pharmaceutically acceptable salt in which the apex of the a83044 ring is NH or C (o)；Each vertex in the A1 and A3 rings is selected independently from the N, NH, CH, C (o) and C (r830808) groups.Every tip of the ring every yeara. A8309a and a8310a were selected independently from groups n, CH and C (r830808)；The top of a 83088 ring is selected from n, n (c8321c83318c24j) group；CH Y C (R)No more than 2 years 3,A8308；A83099a and a8310n； the links on each dotted line are independent single or double line links； R1 is selected from the non orthodox group, arilo c832683121； 8320a；-C₁₋₈-alkylene-heteroaryl, -C₁₋₈-alkylene-C₆₋₁₀-aryl,cycloalkyl C₃₋₈,4 to 8 members of isoprene, on loan c832131；Halogenated tar c83218c8331-8328；-C (O) NR Rand -CO₂R¹ᵃ；Among them, heterocyclic ring a is a ring composed of four to eight members, from 1 to 3 heterocyclic atoms, as the ring vertex selected from n to s； while heterocyclic ring is an aromatic ring composed of five to 10 members, from 1 to 3 heterocyclic atoms, as the ring vertex selected from n to s. C83218c83318328a tar was selected from the hydrogen group by r749191 and r749595；aryl C₆₋₁₀,and -C₁₋₆-alkylene-C₆₋₁₀-aryl；e. R1 can be replaced with 1 to 5 by r83091；Rs749191 and rs74977 were selected from the tenants of c83218331 and 8326267, respectively；C₁₋₆ alkoxy,a. Halogenated tar c83218c833316c2-o-halogenated tar c8321c833126；-S-alkyl C₁₋₆,-C₁₋₆-alkyl-C₁₋₆-alkyl,-C₁₋₆-alkyl-C₁₋₆-alkyl,Cn, and halogen, R 2455,758080,and R²ᵈ are each independently selected from the group consisting of hydrogen, C₁₋₆-alkyl,C₁₋₆ alkoxy,haloalkyl C₁₋₆,-O-halide c8321c833126；-S-alkyl C₁₋₆,-C₁₋₆-alkyl-C₁₋₆-alkyl,-C₁₋₆-alkyl-C₁₋₆-alkyl,cyano, and halogen； each R³ is independently selected from the group consisting of C₁₋₄-alkyl,a. The halogenated tar c83312424y and hydroxyl group can be combined with two R3 in the same carbon atom to form oxo (= O)；each R⁴ is independent
