Каролин Анн ФОСТЕР (AT),Петер С. ХИШТАНД (CH),Пол Уилльям ГЛУ (US)
申请号：
RU2012153692/15
公开号：
RU2012153692A
申请日:
2012.12.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The use of an S1P receptor agonist for the preparation of a medicament for treating, alleviating or delaying the progression of optic neuritis or Guillain-Barré syndrome, where an S1P receptor agonist is a compound of formula IX wherein R is halogen, trihalomethyl, hydroxy, lower alkyl having from 1 to 7 carbon atoms, phenyl, aralkyl, lower alkoxy having from 1 to 4 carbon atoms, trifluoromethyloxy, substituted or unsubstituted phenoxy, cyclohexylmethyloxy, substituted or unsubstituted aralkyloxy, pyri ylmethyloxy, cinnamyloxy, naphthylmethyloxy, phenoxymethyl, hydroxymethyl, hydroxyethyl, lower alkylthio having from 1 to 4 carbon atoms, lower alkylsulfinyl having from 1 to 4 carbon atoms, lower alkylsulfonyl having from 1 to 4 carbon atoms, benzylthio, acetyl, nitro or cyano； R is hydrogen, halogen, trihalogenomethyl, lower alkoxy having from 1 to 4 carbon atoms, lower alkyl having from 1 to 7 carbon atoms, phenethyl or benzyloxy； R is hydrogen, halogen, trifluoromethyl, lower alkoxy having from 1 to 4 carbon atoms, gi Proxy, benzyloxy, lower alkyl having from 1 to 7 carbon atoms, phenyl, or lower alkoxymethyl having 1 to 4 carbon atoms； Xoboznachaet O or S, inoboznachaet integer from 1 to 4, or a pharmaceutically acceptable sol.2. The use according to claim 1, wherein the S1P receptor agonist is administered in conjunction with at least one concomitant agent exhibiting clinical activity against at least one symptom of demyelination disease. Pharmaceutical combination for the preparation of a medicament for treatment, easier1. Применение агониста рецептора S1P для приготовления лекарственного средства для лечения, облегчения или задержки прогрессирования неврита зрительного нерва или синдрома Гийена-Барре, где агонист рецептора S1P представляет собой соединение формулы IXв которойRобозначает галоген, тригалогенметил, гидрокси, низший алкил, имеющий от 1 до 7 атомов углерода, фенил, аралкил, низший алкокси, имеющий от 1 до 4 атомов углерода, трифторметилокси, зам
