REGENERON PHARMACEUTICALS, INC.;YALE UNIVERSITY;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB)
发明人:
HERNDLER-BRANDSTETTER, DIETMAR,FLAVELL, RICHARD A.,FRLETA, DAVOR,GURER, CAGAN,MANZ, MARKUS GABRIEL,MURPHY, ANDREW J.,PALM, NOAH W.,SHAN, LIANG,STEVENS, SEAN,STROWIG, TILL,YANCOPOULOS, GEORGE D.,DE ZOE
申请号：
CA2981186
公开号：
CA2981186A1
申请日:
2016.04.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Genetically modified non-human animals expressing human SIRPa and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPa and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPa and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
