Regeneron Pharmaceuticals, Inc.; Inc.;Institute for Research in Biomedicine (IRB);Yale University;Regeneron Pharmaceuticals
发明人:
Herndler-Brandstetter, Dietmar,Flavell, Richard A.,Frleta, Davor,Gurer, Cagan,Manz, Markus Gabriel,Murphy, Andrew J.,Palm, Noah W.,Shan, Liang,Stevens, Sean,Strowig, Till,Yancopoulos, George D.,De Zoe
申请号：
AU2016247892
公开号：
AU2016247892A1
申请日:
2016.04.12
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various
