INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);REGENERON PHARMACEUTICALS INC.;YALE UNIVERSITY
发明人:
申请号：
IL25472717
公开号：
IL254727D0
申请日:
2017.09.27
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
