HERNDLER BRANDSTETTER DIETMAR,FLAVELL RICHARD A,Frleta Davor,GURER CAGAN,MANZ MARKUS GABRIEL,MURPHY ANDREW J,PALM NOAH W,SHAN LIANG,STEVENS SEAN,STROWIG TILL,YANCOPOULOS GEORGE D,DE ZOETE MARCEL
申请号：
IN201717037451
公开号：
IN201717037451A
申请日:
2017.10.24
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
in vivo Genetically modified non human animals expressing human SIRPa and human IL 15 from the non human animal genome are provided. Also provided are methods for making non human animals expressing human SIRPa and human IL 15 from the non human animal genome and methods for using non human animals expressing human SIRPa and human IL 15 from the non human animal genome. These animals and methods find many uses in the art including for example in modeling human T cell and/or natural killer (NK) cell development and function in modeling human pathogen infection of human T cells and/or NK cells and in various screens.
