Regeneron Pharmaceuticals, Inc.;Yale University;Institute for Research in Biomedicine (IRB)
发明人:
Dietmar Herndler-Brandstetter,Richard A. Flavell,Davor Frleta,Cagan Gurer,Markus Gabriel Manz,Andrew J. Murphy,Noah W. Palm,Liang Shan,Sean Stevens,Till Strowig,George D. Yancopoulos,Marcel de Zoete
申请号：
US15954450
公开号：
US20180295820A1
申请日:
2018.04.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
