MURPHY ANDREW J,STEVENS SEAN,FLAVELL RICHARD,MANZ MARKUS,SHAN LIANG
申请号：
IN201617041483
公开号：
IN201617041483A
申请日:
2016.12.05
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function in modeling human pathogen infection of erythrocytes in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state in screens for agents that are toxic to erythrocytes or erythrocyte progenitors in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.
