REGENERON PHARMACEUTICALS, INC.; INC.;INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);YALE UNIVERSITY;REGENERON PHARMACEUTICALS
发明人:
HERNDLER-BRANDSTETTER, Dietmar,FLAVELL, Richard A.,FRLETA, Davor,GURER, Cagan,MANZ, Markus Gabriel,MURPHY, Andrew J.,PALM, Noah W.,SHAN, Liang,STEVENS, Sean,STROWIG, Till,YANCOPOULOS, George D.,DE ZOE
申请号：
SG11201708380W
公开号：
SG11201708380WA
申请日:
2016.04.12
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
