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Compositions for treating hyperproliferative vascular disorders and cancers
专利权人:
Soo Jung Kang;Gyu Hwan Yon;Eun Bok Choi;Young Doug Sohn;Kwang Hoe Chung;Sung Yu Hong;Hyeon Kyu Lee;Heui Cheol Yang;Chwang Siek Pak;Jae Hoon Hwang
发明人:
Kwang Hoe Chung,Chwang Siek Pak,Sung Yu Hong,Soo Jung Kang,Young Doug Sohn,Jae Hoon Hwang,Eun Bok Choi,Gyu Hwan Yon,Hyeon Kyu Lee,Heui Cheol Yang
申请号:
US12528224
公开号:
US08106071B2
申请日:
2007.05.23
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a method for treating or reducing the development of a hyperproliferative disorder, which comprises administering to a subject a composition,which comprises as an active ingredient the compound represented by the Formula 1:wherein R1, R2, R3, R4, R5, R6 and R7 independently represent hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl or alkylaryl;X and Y independently represent hydrogen, oxygen, or sulfur, bound to a carbon atom via a single or double bond;Z represents hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl, alkylaryl or —NH—R8;R8 represents hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl or alkylaryl;n is an integer of 0-3.
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