THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
JACOBSON, KENNETH A.,MELMAN, ARTEM
申请号：
ES09728154
公开号：
ES2531828T3
申请日:
2009.03.24
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound having a formula selected from formula I and formula II: ** Formula ** wherein, in formula I: R1 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, cycloalkyl C3-C8, cycloalkyl C3-C8-alkyl C1-C6, dicycloalkyl C3-C8-alkyl C1-C6, bicycloalkyl C7-C12-alkyl C1-C6, tricycloalkyl C7-C14-alkyl C1-C6, aryl C6-C14, aryl C6-C14-C1-C6 alkyl, C6-C14 diaryl-C1-C6 alkyl, C6-C14-aryl-C1-C6 alkoxy, heterocyclyl-C1-C6 alkyl, heterocyclyl, 4 - [[[4 - [[(2 - amino-C1-C6 alkyl) amino] -carbonyl] -C1-C6 alkyl] anilino] carbonyl] C1-C6 alkyl] C6-C14 aryl, and C6-C14-C3-C8 cycloalkyl, wherein the aryl portion or R 1 heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of halo, amino, hydroxyl, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1 alkoxy -C6, C6-C14 aryloxy, hydroxy-alkyl C1-C6 yl, C2-C6 hydroxy-alkenyl, C2-C6 hydroxy-alkynyl, C1-C6 carboxy-alkyl, C2-C6 carboxy-alkenyl, C2-C6 carboxy-alkynyl, aminocarbonyl-C1-C6 alkyl, aminocarbonyl-alkenyl C2-C6, aminocarbonyl-C2-C6 alkynyl, and any combination thereof； and the alkyl or cycloalkyl portion of R1 is optionally substituted with one or more substituents selected from the group consisting of halo, amino, alkyl, alkoxy, aryloxy, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, aminocarbonylalkoxy, and arylalkoxy, and any combination thereof； or R1 is 7-nornornyl； R2 is selected from the group consisting of iodine, C1-C20 alkyl, C7-C12 cycloalkyl-C1-C2O alkyl, C7-C12 alkylcycloalkyl-C1-C20 alkyl, C7-C12 cycloalkenyl-C1-C20 alkyl, C6-C14 aryl- C1-C20 alkyl, C2-C20 alkenyl, C7-C12-cycloalkyl-C2-C20 alkynyl, C7-C12-cycloalkyl-C2-C20-alkynyl, C7-C12-cycloalkenyl C2-C20, aryl C6-C14-C2-C20-alkenyl, C2-C20 alkynyl, C1-C20 alkyl-C2-C20 alkynyl, C7-C12-cycloalkyl-C2-C20 alkynyl, C7-C12-cycloalkyl-C2-C20 alkynyl, C7-C12-cycloalkenyl C2-C20-alkynyl, C6-C14-aryl C2-C2O alkynyl, and
