XIONG, YIFENG,FEICHTINGER, KONRAD,REN, ALBERT S.,ULMANN, BRETT
申请号：
ES08795334
公开号：
ES2421237T7
申请日:
2008.08.14
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound selected from the compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates and hydrates thereof: in which: each of R1, R2, R3, R4 and R5 is independently selected from H, C1-C6 acyl , C1-C6 acyloxy, C1-C6 alkoxy, C1-C6 alkoxycarbonylamino, C1-C6 alkyl, C1-C6 alkylamino, C2-C8 dialkylamino, C1-C6 alkylcarboxamide, C1-C6 alkylsulfonamide, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl , C1-C6 alkylureyl, amino, aryl, arylC1-C4 alkynyl, C1-C6 carboxy-alkoxy, carboxamide, carboxy, cyano, C3-C7 cycloalkyl, C2-C6 dialkylcarboxamide, C1-C6 haloalkoxy, C1-C6 haloalkyl, C1-C6 haloalkyl -C6, C1-C6 haloalkylsulfonyl, halogen, heteroaryl, heterocyclyl, hydroxyl, nitro and sulfonamide； each of R6 and R7 is independently selected from H, C1-C6 acyl, C1-C3 alkyl, aryl, carboxamide, carboxy, C3-C7 cycloalkyl, C1-C6 haloalkyl, heteroaryl and heterocyclyl； each of R8 and R9 is independently selected from H, C1-C6 acyl, C1-C3 alkyl, aryl, carboxamide, C1-C3 alkoxy, carboxy, cyano, C3-C7 cycloalkyl, C1-C3 haloalkyl, halogen and hydroxyl； or R8 and R9 considered together, form oxo； or R8 and R9, together with the atom to which they are both linked, form a C3-C7 cycloalkyl ring； and each of R10, R11, R12, R13 and R14 is independently selected from H, C1-C6 acyl, C1-C6 acyloxy, C1-C6 alkoxy, C1-C6 alkoxycarbonylamino, C1-C6 alkyl, C1-C6 alkylamino, C1-alkylcarboxamide -C6, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonamide, C1-C6 alkylsulfonyl, C1-C6 alkylureyl, amino, C1-C6 carboxyalkoxy, carboxamide, carboxy, cyano, C3-C6 cycloalkyl, C3-C7 cycloalkylcarbonyl, C2 dialkylamino -C8, C2-C6 dialkylcarboxamide, C1-C6 haloalkoxy, C1-C6 haloalkyl, C1-C6 haloalkylsulfinyl, C1-C6 haloalkylsulfonyl, halogen, heteroaryl, heterocyclyl, hydroxyl, nitro, phenyl, sulfonamide and sulfonic acid； wherein said phenyl group is optionally substituted with 1, 2 or 3 halogens.Un compuesto seleccionado entre los compuestos de la Fórmula (Ia) y sales farmacéuticamente aceptables,solvatos e hidrato
