ДРАЙГИН Денис (US),ХО Кэролайн Б (US),БЛИЗЭТ Джошуа Р. (US),ПРОФФИТТ Кристофер Б. (US),ОБРАЙН Шон (US),ЭНДЕРС Кенна (US)
申请号：
RU2011133093/15
公开号：
RU2011133093A
申请日:
2009.06.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method for treating or ameliorating a neoplastic disease comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof, wherein Zpredstavlyaet is N or CR each R, R, r and independently represents H or optionally substituted C1-C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 geteroalkenilnuyu, C2-C8 alkynyl, C2-C8 geteroalkinilnuyu, C1-C8 acyl, C2-C8 geteroatsilnuyu, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or C6-C12 heteroarylalkyl group, or each R, R, r and independently represents halogen, CF, CFN, OR, NR, NROR, NRNR, SR, SOR, SOR, SONR, NRSOR, NRCONR, NRCOOR, NRCOR, CN, COOR, bioisostere carboxy, CONR, OOCR, COR, or NO, each R is, independently, optionally substituted C1-C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 geteroalkenilnuyu C2 -S8 alkynyl, C2-C8 geteroalkinilnuyu, C1-C8 acyl, C2-C8 geteroatsilnuyu, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or C6-C12 heteroarylalkyl group, Iliko zhdy R is, independently, halo, OR, NR, NROR, NRNR, SR, SOR, SOR, SONR, NRSOR, NRCONR, NRCOOR, NRCOR, CN, COOR, CONR, OOCR, COR, or NO, wherein each R represents, independently, H or C1-C8 alkyl, C2-C8 heteroalkyl, C2-C8 alkenyl, C2-C8 heteroalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C2-C8 geteroatsil, C6-C10 aryl, C5 -S10 heteroaryl, C7-C12 arylalkyl or C6-C12 heteroarylalkyl, and wherein two R on the same atom or adjacent atoms may be joined to form a 3-8 membered ring optionally containing one or more atoms are N, O, or S and each group R, and each ring paying
