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BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS
专利权人:
The University of British Columbia;Provincial Health Services Authority
发明人:
Raymond J. Andersen,Marianne Dorothy Sadar,Kunzhong Jian,Nasrin R. Mawji,Jun Wang,Carmen Adriana Banuelos,Yu-Chi Yang
申请号:
US16848061
公开号:
US20200317628A1
申请日:
2020.04.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Compounds having a structure of Formula Ior a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
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