CAO, Sheldon,POPOVICI-MULLER, Janeta,SALITURO, Francesco G.,SAUNDERS, Jeffrey O.,TAN, Xuefei,TRAVINS, Jeremy,YAN, Shunqi,YE, Zhixiong,CAO SHELDON,CAO, SHELDON,POPOVICI-MULLER JANETA,POPOVICI-MULLER, JANETA,SALITURO FRANCESCO G,SALITURO, FRANCESCO G.,SAUNDERS JEFFREY O,SAUNDERS, JEFFREY O.,TAN XUEFEI,TAN, XUEFEI,TRAVINS JEREMY,TRAVIN
申请号：
ES12799802
公开号：
ES2618637T3
申请日:
2012.06.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having Structural Formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, in which: X is CR4； Y is -N (R5) - or -CH (R5) -； Z is -O-, -S-, -C (R) 2- or N (R7)； W is C (R1) (R1) or N (R7)； with the proviso that Z and W are not both N (R7) at the same time； V is N or C (R)； each R is independently selected from hydrogens, methyl or CF3； each R1 is independently selected from hydrogen, alkoxy, or alkyl optionally substituted with OH or SH； or two R1 are taken together with the carbon atom to which they are attached to form a 3-7 membered cycloalkyl, or a 4-7 membered saturated heterocyclyl ring in which said cycloalkyl or heterocyclyl is optionally substituted with methyl, halo or CF3； R2 is selected from phenyl, 3-7 membered cycloalkyl, C2-C4 alkyl or CF3, wherein the phenyl or cycloalkyl is optionally substituted with a single substituent selected from methyl, CF3 or fluorine； each R3 is independently selected from - (C1-C4 alkylene) -O- (C1-C4 alkyl), -C1-C4-fluoroalkyl, -C (O) -O- (C1-C4 alkyl), -phenyl, -heteroaryl, C3-C7 cycloalkyl, -CH2-N (C1-C4 alkyl) 2, C (O) -N- (C1-C4 alkyl) 2, -C (O) -NH- (C1-C4 alkyl), -C1 alkyl -C4 optionally substituted with halo or -OH, or two R3 are taken together to form a 3-8 membered saturated ring or a condensed phenyl wherein said saturated or condensed phenyl ring is optionally substituted with 1 to 2 methyl； R4 is selected from hydrogen, -CN, halo, C1-C4 alkoxy, -CH2NH (C1-C4 alkyl), C2-C4 alkenyl, C2-C4 alkynyl, - (C1-C4 alkyl) -O- (C1-C4 alkyl ), C1-C4 fluoroalkyl, C (O) -N- (C1-C4 alkyl) 2, -C (O) -NH- (C1-C4 alkyl), -S (O) 2- (C1-C4 alkyl) , and a 5-membered heteroaryl； R5 is selected from: C1-C4 alkyl, -C (O) - (C1-C4 alkyl), -C (O) - (C0-C2 alkylene) -Q, -C (O) - (C0-C2 alkylene) -N (R6) - (C0-C2 alkylene) -Q, -C (O) -O- (C0-C2 alkylene) -Q, -C (O) - (C1-C2 alkylene) -O- (C0 alkylene -C2) -Q, -C (O) -C (O) -Q, - S (O) 2-Q, -C (O) - (C1-C4 alkylene) -OC (O) - (C1-alkyl C4), -C (O) - (C1-C4 alkyle
