A compound of the formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: D is C, both E and B are N, and A is N or CR； each R is independently selected from hydrogen, halo, OH, C≡N, C1-C4 alkyl, halo-substituted C1-C4 alkyl, C1-C4 alkyl substituted C1-C4 alkoxy, hydroxy-substituted C1-C8 alkyl, O-R3 , -O- (C1-C4 alkyl) -OR3, S- (C1-C4 alkyl), S- (halo-substituted C1-C4 alkyl), N (hydroxy-substituted C1-C4 alkyl) 2, N (C1 alkyl -C4 methoxy-substituted) 2, N (C1-C4 alkyl) (C1-C4 alkyl hydroxy-substituted), N (C1-C4 alkyl) (C1-C4 alkyl methoxy-substituted), C3-C7 cycloalkyl, and non-heterocycle aromatic 4 to 8 members； R1 is a monocyclic aromatic heterocycle, wherein R1 is optionally substituted with one or more substituents independently selected from halo, C≡N, C1-C4 alkyl, halo-substituted C1-C4 alkyl, C1-C4 alkyl substituted C1-C4 alkoxy, hydroxy-substituted C1-C8 alkyl, O-R3, O- (C1-C4 alkyl) -OR3,>； = O, C3-C7 cycloalkyl, SO2R3, S-R3, (C1-C4 alkyl) -N (R3) ( R3), N (R3) (R3), O- (C1-C4 alkyl) -N (R3) (R3), O- (C0-C4 alkyl) -CR3R3- (C0-C4 alkyl), (C1- alkyl C4) -O- (C1-C4 alkyl) -N (R3) (R3), C (>； = O) -N (R3) (R3), (C1-C4 alkyl) -C (>； = O) -N (R3) (R3), O- (C0-C4 alkyl) -CRxRx- (C0-C4 alkyl), CRxRx, phenyl, O-phenyl, second heterocycle, O- (second heterocycle), 3,4-methylenedioxy, 3 , Halo-substituted 4-methylenedioxy, 3,4-ethylenedioxy and halo-substituted 3,4-ethylenedioxy, wherein any substituent phenyl, saturated heterocycle or second heterocycle of R1 is optionally substituted with one or more substituents independently selected from halo, C ≡N, C1-C4 alkyl, C1-C4 alkyl halo-su stituido, O- (halo-substituted C1-C4 alkyl), O- (C1-C4 alkyl), S- (C1-C4 alkyl), S- (halo-substituted C1-C4 alkyl), and N (R3) ( R3), and R1 may additionally be a bicyclic aromatic heterocycle； R2 is a heterocycle or an aromatic carbocycle, wherein R2 is optionally substituted with one or more substituents independently selected from fluorine, bromi
