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Neprilysin inhibitors
- 专利权人:
- Theravance Biopharma R&D IP; LLC
- 发明人:
- GENDRON, Roland,HUGHES, Adam D.
- 申请号：
- ES12725202
- 公开号：
- ES2653215T3
- 申请日:
- 2012.05.18
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- Compound of formula I: ** (See formula) ** in which: R1 is -OR10 or -NR60R70, R2 is H or -OR20, R3 is selected from H, Cl, F, -CH3 and -CF3, R4 is selected from H, C1-6 alkyl, C2-3-alkylene, - [(CH2) 2O] 1-3CH3, C1-3-C (O) alkylene OR40； - CH2-C (O) NR41R42； C0-2-pyridine alkyl optionally substituted with halo, -CH2-isoxazole optionally substituted with methyl, -CH2-pyrimidine optionally substituted with -O-C1-6 alkyl, -C2-alkylene-phenyl, ** (See formula) ** R5 is selected from H, halo, -C0-5-OH alkylene, -NH2, C1-6 alkyl, -CF3, C3-7 cycloalkyl, -C0-2-alkyl-C1-6 alkyl, -C (O) R50, -C0-1-C (O) alkylene OR51 -C (O) NR52R53, -NHC (O) R54, -NO2, furan, pyrazine, naphthalene, pyridine, optionally substituted pyrazole with methyl, thiophene optionally substituted with methyl and phenyl optionally substituted with one or two groups independently selected from halo, -OH, -CF3, -OCH3, -NHC (O) CH3 and phenyl, R10, R40 and R51 are independently selected from H, C1-6 alkyl, - C1-3 alkyl-C6-10 aryl, - 25 C1-3 alkyl-C1-9 heteroaryl, C3-7 cycloalkyl, - [(CH2) 2O] 1-3CH3, -C1-6-OC alkylene (O) R13, -C1-6- NR14R15 alkylene, -C1-6-C alkylene (O) R17, -C0-6 alkylene-morpholine, -C1-6-SO2-C1-6 alkyl, ** (See formula) ** ...Compuesto de fórmula I: **(Ver fórmula)** en la que: R1 es -OR10 o -NR60R70, R2 es H o -OR20, R3 se selecciona de entre H, Cl, F, -CH3 y -CF3, R4 se selecciona de entre H, alquilo C1-6, alquileno C2-3-OH, -[(CH2)2O]1-3CH3, alquilén C1-3-C(O)OR40； - CH2-C(O)NR41R42； alquilén C0-2-piridina sustituida opcionalmente con halo, -CH2-isoxazol sustituido opcionalmente con metilo, -CH2-pirimidina sustituida opcionalmente con -O-alquilo C1-6, -alquilén C2- fenilo, **(Ver fórmula)** R5 se selecciona de entre H, halo, -alquilén C0-5-OH, -NH2, alquilo C1-6, -CF3, cicloalquilo C3-7, -alquilén C0-2-O-alquilo C1-6, -C(O)R50, -alquilén C0-1-C(O)OR51 -C(O)NR52R53, -NHC(O)R54, -NO2, furano, pirazina, naftaleno, piridina, pirazol sustituido opcionalmente con metilo, tiofeno sustituido
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
