HU, Lili,DEMIN, Samuël,VENDEVILLE, Sandrine,TAHRI, Abdellah,RABOISSON, Pierre
申请号：
ES15714532
公开号：
ES2669995T3
申请日:
2015.04.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I) ** Formula ** including any stereochemically isomeric form thereof, wherein Het is a heterocyclic moiety of any of the following formulas (a), (b) or (c): ** Formula ** Q is CH2 or CH2CH2； V is CH2 or CH2CH2； Z is CH or N； R1 is C1-6 alkyl； C3-6 cycloalkyl； C3-6 cycloalkyl substituted with hydroxy； Het1； or C1-6 alkyl substituted with a substituent selected from halo, hydroxy, polyhalo-C1-4 alkyl, NR5R6, Het2, C3-6 cycloalkyl or C3-6 cycloalkyl substituted with hydroxy； wherein R5 is hydrogen or C1-4 alkyl； and R6 is hydrogen or C1-4 alkyl； R2 is hydrogen or C1-6 alkyl； R3 is halo； R4 is - (CH2) m-R7； m is an integer from 2 to 4； R7 is halogen, CN, CF3 or SO2CH3； and Het1 is azetidinyl, pyrrolidinyl, piperidinyl or tetrahydropyranyl； wherein Het1 is optionally substituted with C1-4 alkyl, polyhalo-C1-4 alkyl or C1-4 alkyloxycarbonyl； Het2 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl or tetrahydropyranyl； wherein Het2 is optionally substituted with C1-4 alkyl or polyhalo-C1-4 alkyl； or a salt by pharmaceutically acceptable acid addition thereof.Un compuesto de fórmula (I)**Fórmula** incluyendo cualquier forma estereoquímicamente isómera del mismo, en donde Het es un resto heterocíclico de cualquiera de las siguientes fórmulas (a), (b) o (c):**Fórmula** Q es CH2 o CH2CH2； V es CH2 o CH2CH2； Z es CH o N； R1 es alquilo C1-6； cicloalquilo C3-6； cicloalquilo C3-6 sustituido con hidroxi； Het1； o alquilo C1-6 sustituido con un sustituyente seleccionado de halo, hidroxi, polihalo-alquilo(C1-4), NR5R6, Het2, cicloalquilo C3-6 o cicloalquilo C3-6 sustituido con hidroxi； en donde R5 es hidrógeno o alquilo C1-4； y R6 es hidrógeno o alquilo C1-4； R2 es hidrógeno o alquilo C1-6； R3 es halo； R4 es -(CH2)m-R7； m es un número entero de 2 a 4； R7 es halógeno, CN, CF3 o SO2CH3； y Het1 es azetidinilo, pirrolidinilo, piperidinilo o tetrahidropiranilo； en donde Het1 está opcionalmente sustituido con alquilo C1-4, polihalo-alquilo(C1-4) o alq
