VAN BRANDT, SVEN,DE CLEYN, MICHEL,GIJSEN, HENRICUS,BERTHELOT, DIDIER,SURKYN, MICHEL
申请号：
ES11700832
公开号：
ES2523977T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula (I) ** Formula ** or a stereoisomeric form thereof, in which Het1 is a heterocycle, having the formula (a-1), (a-2), (a-3) or (a -4) ** Formula ** R3 is C1-4 alkyl； R4, R5, R6 and R8 are each independently hydrogen or C1-4 alkyl optionally substituted with one or more halo substituents； R7a is hydrogen, halo or C1-4 alkyl； R7b and R7c are each independently hydrogen, halo, cyano, C1-4 alkyloxy, C3-7 cycloalkyl or C1-4 alkyl optionally substituted with one or more halo substituents； Xa is CH or N； Xb is O or S； A1 is CR9 or N； wherein R9 is hydrogen, halo or C1-4 alkyloxy； A2, A3 and A4 are each independently CH or N； provided that at most two of A1, A2, A3 and A4 are N； L1 is O, carbonyl, NR10, NH- (C>； = O) or (C>； = O) -NH； wherein R10 is hydrogen or C1-4 alkyl； R1 is C3-7 cycloalkyl； C2-6 alkenyl； or C1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo, cyano, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NR11aR12a, C3-7 cycloalkyl and C1-6 alkyloxy； wherein each C3-7 cycloalkyl may be substituted with one or more substituents each independently selected from the group consisting of halo, C1-4 alkyloxy, cyano and C1-4 alkyl optionally substituted with one or more halo substituents； L2 represents a direct link； carbonyl； OR； S； S (>； = O) p； NR13a； NR13b-C1-3 alkanediyl； C1-3-NR13c alkanediyl； C1-3 alkanediyl optionally substituted with one or more halo substituents； or C1-3 alkanediyl in which two geminal hydrogen atoms may be replaced by C2-6 alkanediyl； p represents 1 or 2.Compuesto de fórmula (I)**Fórmula** o una forma estereoisomérica del mismo, en la que Het1 es un heterociclo, que tiene la fórmula (a-1), (a-2), (a-3) o (a-4) **Fórmula** R3 es alquilo C1-4； R4, R5, R6 y R8 son cada uno independientemente hidrógeno o alquilo C1-4 opcionalmente sustituido con uno o más sustituyentes halo； R7a es hidrógeno, halo o alquilo C1-4； R7b y R7c son cada uno independiente
