THURING, JOHANNES WILHELMUS JOHN F.,MACDONALD, GREGOR,ZHUANG, WEI
申请号：
ES09742162
公开号：
ES2525132T3
申请日:
2009.05.08
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound according to formula (I) ** Formula ** or a stereochemically isomeric form thereof, in which: Z is C1-6 alkyl substituted with one or more substituents independently selected from the group consisting of hydroxyl, R1R2N-C (>； = O) -, R310 OC (>； = O) - and halo； Q is 2,2-difluorobenzodioxole-5-yl； L is phenyl, pyridinyl or benzodioxanyl, each optionally substituted with one, two or more substituents independently selected from the group consisting of halo, cyano, C1-6 alkyl, C1-6-O- alkyl, C1-6-S-alkyl , C1-6 polyhaloalkyl, C1-6-O- polyhaloalkyl, mono- and di (C1-6 alkyl) amino, pyrrolidinyl, piperidinyl, morpholinyl, CH3 C1-6 alkyl-NH-, HO-C1-6-NH- alkyl, C3-6 cycloalkyl, C3-6-NH- cycloalkyl, C3-6-cycloalkyl C1-6-NH-, C1-6-alkyl-C1-6alkyl, methoxycarbonyl and C3-6-O-C1-6 alkyl -； R 1 and R 2 each independently represent hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkyl-C 1-6 alkyl or C 3-6 cycloalkyl-C 1-6 alkyl； or R1 and R2 taken together with the nitrogen atom to which they are attached form a heterocyclic radical selected from the group consisting of pyrrolidinyl, piperidinyl and morpholinyl, each optionally substituted with one, two or three substituents each independently selected from the group consisting in halo, hydroxyl and C1-6 alkyl； R3 is hydrogen or C1-3 alkyl； or a pharmaceutically acceptable addition salt, or a hydrate or a solvate thereof.Compuesto según la fórmula (I)**Fórmula** o una forma estereoquímicamente isomérica del mismo, en la que: Z es alquilo C1-6 sustituido con uno o más sustituyentes seleccionados independientemente del grupo que consiste en hidroxilo, R1R2N-C(>；=O)-, R310 O-C(>；=O)- y halo； Q es 2,2-difluorobenzodioxol-5-ilo； L es fenilo, piridinilo o benzodioxanilo, cada uno opcionalmente sustituido con uno, dos o más sustituyentes seleccionados independientemente del grupo que consiste en halo, ciano, alquilo C1-6, alquil C1-6-O-, alquil C1-6-S-, polihaloalquilo C1-6, polihaloalquil C1-6-O-, mono- y di(alquil C
